Buclizine may cause drowsiness and patients taking the drug should be cautioned against engaging in activities requiring mental alertness like driving automobile. It may enhance the sedative effect of nervous depressants including alcohol, barbiturates, hypnotics, narcotics, analgesic, sedative and tranquilizers. It may be distributed in milk and inhibit lactation. Some antihistamines have been reported to affect the metabolism of drug in the liver.
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